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Vysnova Task Order: Identification of Gene Mutation in the Insecticide-Resistant Mosquito Population in Vietnam Using Next Generation Sequencing

TO22F-0121, Gene Mutation Vietnam, 19 September 2022 – 18 September 2023

The main objectives of this project are to assess the insecticidal resistance (IR) and IR mechanisms in Aedes mosquitoes to pyrethroids, organophosphates, carbamates, and the underlying mechanisms in SE Asia to better inform DoD force health protection policy makers and to provide host-nation public health personnel information to make informed diagnostic and treatment decisions.

What is Insecticide Resistance?

Insecticide resistance is defined by the Insecticide Resistance Action Committee (IRAC) as ‘a heritable change in the sensitivity of a pest population that is reflected in the repeated failure of a product to achieve the expected level of control when used according to the label recommendation for that pest species’. In other words, it is an inherited ability of a population to survive a lethal concentration of an insecticide product that would normally kill a wild population. This is due to alleles that confer appropriate resistance factors, which subsequently increase in frequency in response to insecticide selection pressure. However, insecticide resistance is not to be confused with insecticide tolerance. Unlike insecticide resistance, the latter is the natural ability to withstand insecticide action, and is not the result of genetic changes caused by the insecticide selection pressure.

About Vysnova Partners Inc.

Vysnova Partners, Inc. is a program management firm that delivers a broad range of professional, technical and institutional support services in Public/Global Health, Research and Development (R&D) in the Life Sciences, and Government Operations and Acquisition on a global basis. As an implementing partner to the U.S. Government in the United States and overseas, Vysnova ensures that all program activities are compliant with all Federal Acquisition Regulations (FAR), other Agency-specific regulations, and local laws.