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Project Spotlight: MRS SEA

 

Project Purpose

NAMRU-2 has funded Vysnova Partners to execute research re-stratifying the epidemiology of Malaria in Vietnam. The project will also identify more effective control and elimination interventions, and enhance malaria case detection to inform the Vietnam Ministry of Health.

Vysnova’s Work

Vysnova has executed several studies in collaboration with the National Institute of Parasitology, Malariology, and Entomology (NIMPE), since November 2015, including the case-control study. 

“Molecular and genetic epidemiology for Malaria in drug-resistant areas of Vietnam: A case-control study of risk factors,” based on a protocol designed by the Mahidol Oxford Research Unit (MORU).

This study combined patient interviews with the collection of blood samples and GPS coordinates. Blood samples from this study were analyzed in NIMPE’s laboratory, and some blood samples were sent for Sanger Sequencing via Oxford University Clinical Research Unit (OUCRU) to the Sanger Institute.

The Vysnova Impact 

The studies will identify the incidence of imported Malaria in Binh Phuoc, Gia Lai, and Dak Nong in Vietnam. It will quantify and map genetic markers of P. falciparum drug resistance cases in Gia Lai, Binh Phuoc, and Dak Nong. It will also identify the risk of Malaria transmission in mobile populations in Gia Lai, Binh Phuoc, and Dak Nong. It will identify and map the incidence of low-grade malaria not detected by conventional microscopy in Binh Phuoc, Gia Lai, and Dak Nong. The project will collect data on the artemisinin drug resistance rate and drug (DHA-PQP) in Vietnam through genetic markers. MORU (Mahidol Oxford Research Unit) is currently drafting a manuscript for the study for publication.